It can be confusing when you receive an entirely different diagnosis for your condition through a second opinion. A change in diagnosis can result in a different treatment option. In this case, you talk to both the doctors. Ask them for the proofs, like lab reports, imaging tests, etc., to support your diagnosis. Assessing your condition with blood tests and imaging can provide you clarity and reassurance. You can also learn about your condition through proper research. Researching the condition can help you decide which treatment options work for you. 

Most of the people seek a second opinion if the proposed treatment strategy is an invasive procedure. For instance, Jim Sitko, a 70-year-old male patient, had a small lesion beneath the tongue. He consulted an oral surgeon for the same, who took samples for biopsy that came out with the devastating news of squamous cell carcinoma of the tongue. The suggested treatment plan was a major surgery that included the removal of a whole portion of the tongue. The removed portion must be rebuilt with tissues and veins from other body parts. Sitko went for a second opinion, and his samples were taken for biopsy. After checking three samples, the pathology results did not show cancer. The doctor used laser treatment for the removal of non-cancerous cells. As a result, the doctor performed a less invasive treatment procedure, which improved the treatment outcomes and prevented the need for major surgery.